BDT 253Pharmaceutical Calculations

Systems of Measurement

11 minute read

What you will learn

  • Use metric units and prefixes for mass, volume and length
  • Convert between metric units
  • State the apothecaries' and avoirdupois weights and measures
  • Convert between metric and older systems using equivalents
  • Use household measures and convert between Celsius and Fahrenheit
  • Write units safely on prescriptions and labels

Key points

  • The metric system is the standard in pharmacy. Its base units are the gram for mass and the litre for volume.
  • Prefixes show size: kilo 1 000, milli 0.001, micro 0.000001. Each step between mass units is a factor of 1 000.
  • To go from a larger unit to a smaller one, multiply. To go from a smaller unit to a larger one, divide.
  • The apothecaries' and avoirdupois systems are old systems still found in some books and on some labels. The two ounces are different.
  • Useful equivalents: 1 grain = 64.8 mg, 1 kg = 2.2 lb, 1 fluid ounce (imperial) = 28.4 mL.
  • A household teaspoon is taken as 5 mL and a tablespoon as 15 mL. Use measuring spoons because kitchen spoons vary.
  • Write units in full where there is a risk of confusion, for example 'micrograms' and 'units'.

Why systems of measurement matter

Medicines are measured by mass, volume and length. Most of pharmacy now uses the metric system, but older systems still appear in some books, old prescriptions and imported labels. You need to read all of them and convert safely.

The metric system

The metric system is based on powers of ten, which makes conversion simple.

QuantityBase unitSymbol
Massgramg
VolumelitreL
Lengthmetrem

Prefixes

PrefixSymbolMeaning
kilok1 000
decid0.1
centic0.01
millim0.001
microµ or mc0.000 001
nanon0.000 000 001

Mass and volume tables

Mass
1 kilogram (kg)1 000 grams
1 gram (g)1 000 milligrams (mg)
1 milligram (mg)1 000 micrograms
1 microgram1 000 nanograms
Volume
1 litre (L)1 000 millilitres (mL)
1 decilitre (dL)100 mL
1 millilitre (mL)1 cubic centimetre (cm³)

Converting within the metric system

  • Larger unit to smaller unit: multiply (the number gets bigger).
  • Smaller unit to larger unit: divide (the number gets smaller).
ConversionWorkingAnswer
0.25 g to mg0.25 × 1 000250 mg
750 mg to g750 ÷ 1 0000.75 g
500 micrograms to mg500 ÷ 1 0000.5 mg
1.5 L to mL1.5 × 1 0001 500 mL
2.5 kg to g2.5 × 1 0002 500 g
0.06 g to mg0.06 × 1 00060 mg

The apothecaries' system

The apothecaries' system was once the standard for dispensing. It is still found in older reference books.

Weight

UnitEquals
20 grains (gr)1 scruple
3 scruples1 drachm (60 grains)
8 drachms1 ounce (480 grains)
12 ounces1 pound (5 760 grains)

Fluid measure (imperial)

UnitEquals
60 minims (min)1 fluid drachm
8 fluid drachms1 fluid ounce
20 fluid ounces1 pint
8 pints1 gallon

The American pint and fluid ounce are different sizes from the imperial ones. Check which system a book or label uses.

The avoirdupois system

The avoirdupois system is used for everyday goods and is the system found in the shop.

UnitEquals
437.5 grains1 ounce (oz)
16 ounces1 pound (lb), 7 000 grains

The grain is the same in both systems, but the ounce is not: the apothecaries' ounce is 480 grains and the avoirdupois ounce is 437.5 grains.

Equivalents

ItemExactApproximate
1 grain64.8 mg65 mg
1 minim0.0592 mL0.06 mL
1 ounce (avoirdupois)28.35 g28 g
1 pound453.6 g454 g
1 kilogram2.205 lb2.2 lb
1 fluid ounce (imperial)28.4 mL
1 pint (imperial)568 mL

Worked conversions

  • 5 grains to mg: 5 × 64.8 = 324 mg exact. With the approximate value of 65 mg, 5 × 65 = 325 mg.
  • 2 fluid ounces to mL: 2 × 28.4 = 56.8 mL.
  • 8 ounces (avoirdupois) to g: 8 × 28.35 = 226.8 g.
  • A patient weighs 154 lb. Weight in kg? 154 ÷ 2.2 = 70 kg.
  • Half an imperial pint in mL: 568 ÷ 2 = 284 mL.

Household measures

MeasureVolume
1 teaspoonful5 mL
1 dessertspoonful10 mL
1 tablespoonful15 mL

Ordinary kitchen spoons vary widely in size. For accuracy, give the patient a 5 mL measuring spoon, an oral syringe or a measuring cup. A bottle of 100 mL at 5 mL per dose holds 100 ÷ 5 = 20 doses.

Temperature

°F = (°C × 9/5) + 32
°C = (°F − 32) × 5/9
ExampleWorkingAnswer
37°C to °F37 × 1.8 = 66.6, + 3298.6°F
25°C to °F25 × 1.8 = 45, + 3277°F
104°F to °C(104 − 32) = 72, × 5/940°C
2°C to °F2 × 1.8 = 3.6, + 3235.6°F
8°C to °F8 × 1.8 = 14.4, + 3246.4°F

A refrigerator for medicines is normally kept between 2°C and 8°C, which is 35.6°F to 46.4°F.

Writing units safely

Unclear units cause serious errors. Follow these habits:

  • Write "microgram" in full, or "mcg", rather than "µg". The "µ" can be misread as "mg", which is a thousand times larger.
  • Write "units" in full, never "U", which can be read as a zero.
  • Write "mL" and not "cc".
  • Use a zero before a decimal point (0.5 mg) and no zero after a whole number (5 mg).
  • Leave a space between the number and the unit.

Exam focus

  • Metric conversions are tested in nearly every paper: mg to g, mL to L, micrograms to mg.
  • Know the apothecaries' tables, especially 20 grains = 1 scruple, 3 scruples = 1 drachm and 8 drachms = 1 ounce.
  • Know that 1 apothecaries' ounce is 480 grains and 1 avoirdupois ounce is 437.5 grains.
  • Temperature conversion between Celsius and Fahrenheit, often for storage conditions.
  • Common mistake: multiplying when you should divide. Check that smaller units give bigger numbers.

Quick check

Test yourself before you move on. Pick an answer to see the explanation.

  1. 1.0.25 g expressed in milligrams is:

  2. 2.500 micrograms is equal to:

  3. 3.In the apothecaries' system, one ounce contains:

  4. 4.In metric dispensing, one teaspoonful is taken as:

  5. 5.37°C expressed in degrees Fahrenheit is:

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