BDT 253Pharmaceutical Calculations

Numbers, Numerals and Decimals

10 minute read

What you will learn

  • Distinguish between a number and a numeral, and name the kinds of numeral
  • Read and write Roman numerals as they appear on prescriptions
  • Use place value, decimal notation and standard form
  • Convert between fractions, decimals and percentages
  • Count significant figures and round answers sensibly
  • Estimate an answer to check that a calculation is the right size

Key points

  • A number is an amount. A numeral is the symbol used to write it, such as 5, five or V.
  • Arabic numerals (0 to 9) are used for calculating. Roman numerals still appear on older prescriptions.
  • Each digit has a place value, so moving a decimal point one place changes the size of a number ten times.
  • Fractions, decimals and percentages are three ways of writing the same amount: 1/4 = 0.25 = 25%.
  • Significant figures show how precisely a quantity is known. Leading zeros do not count.
  • Round only at the end of a calculation, and round to a quantity that your balance or measure can actually deliver.
  • Always estimate first. A decimal point in the wrong place can cause a tenfold dosing error.

Numbers and numerals

A number is an idea of quantity. A numeral is the symbol we use to write it. The words "five", the symbol 5 and the Roman symbol V are three different numerals for the same number.

Kinds of numeral

KindSymbolsWhere you meet it
Arabic numerals0, 1, 2, 3, 4, 5, 6, 7, 8, 9All calculations, labels and records
Roman numeralsI, V, X, L, C, D, MSome older prescriptions, labels and reference books

Roman numerals

SymbolIVXLCDM
Value1510501005001000

The rules are short:

  1. Symbols of equal or falling value are added: VIII = 5 + 3 = 8, and XV = 10 + 5 = 15.
  2. A smaller symbol placed before a larger one is subtracted: IV = 5 − 1 = 4, IX = 10 − 1 = 9, XL = 50 − 10 = 40.
  3. A symbol is not repeated more than three times in a row.

Worked examples:

  • XIV = 10 + 4 = 14
  • XXIX = 20 + 9 = 29
  • XLII = 40 + 2 = 42

On older prescriptions the numbers are often written in small letters, and the last "i" may be written as "j", so iij means 3. The sign ss means one half.

Fractions, decimals and percentages

These are three ways of writing the same amount.

FractionDecimalPercentage
1/20.550%
1/40.2525%
3/40.7575%
1/50.220%
1/80.12512.5%
1/100.110%
1/200.055%
1/30.333...33.3%
  • Fraction to decimal: divide the top by the bottom. 3/8 = 3 ÷ 8 = 0.375.
  • Decimal to percentage: multiply by 100. 0.375 = 37.5%.
  • Decimal to fraction: write it over 10, 100 or 1000, then simplify. 0.125 = 125/1000 = 1/8.

Place value, notation and standard form

Every digit has a place value. In the number 345.678:

Digit345.678
Placehundredstensunitstenthshundredthsthousandths

Moving the decimal point one place to the right makes the number ten times bigger. Moving it one place to the left makes it ten times smaller. This is why a misplaced decimal point causes a tenfold error.

Standard form writes a number as a value between 1 and 10 multiplied by a power of ten. It is useful for very large or very small amounts.

  • 3 500 = 3.5 × 10³
  • 0.0025 = 2.5 × 10⁻³
  • 0.00005 = 5 × 10⁻⁵

Working with decimals

Adding and subtracting: line up the decimal points.

12.500
 0.375
------
12.875

Multiplying: multiply as whole numbers, then give the answer as many decimal places as the two numbers had together. 0.25 × 0.4: 25 × 4 = 100, and there are 3 decimal places in total, so the answer is 0.100 = 0.1.

Dividing: move the decimal point in both numbers by the same number of places until you are dividing by a whole number. 4.5 ÷ 0.09 becomes 450 ÷ 9 = 50.

Writing decimals safely

  • Always put a zero before the decimal point: write 0.5 mg, never .5 mg.
  • Never put a zero after a whole number: write 5 mg, never 5.0 mg.

A missed decimal point can turn 0.5 mg into 5 mg, and a trailing zero can turn 5.0 mg into 50 mg. Both are ten-fold overdoses.

Significant figures

Significant figures are the digits that tell us how precisely a quantity is known.

NumberSignificant figuresWhy
4 0574A zero between non-zero digits counts
0.00722Zeros before the first non-zero digit do not count
0.004503A zero after the decimal point at the end counts
2.503The final zero shows the quantity was measured to the hundredth
125.04Same rule
1 200unclearCould be 2, 3 or 4. Write 1.2 × 10³ to show 2

Rounding

  1. Find the last digit you want to keep.
  2. Look at the digit after it. If it is 5 or more, round up. If it is less than 5, leave it as it is.

Examples:

  • 3.4567 to 2 decimal places = 3.46
  • 0.0724 to 2 significant figures = 0.072
  • 112.78 to 1 decimal place = 112.8

Round only at the end. Keep extra digits while you calculate, then round the final answer to a quantity that your equipment can actually deliver. A balance that reads to 0.01 g cannot weigh 7.4562 g, so weigh 7.46 g. A measure marked in 1 mL steps cannot measure 112.8 mL, so you measure 113 mL or use a smaller measure.

Estimation

Estimating means rounding the numbers to easy ones to find roughly how big the answer should be. Do this before you calculate and again after.

  • 19.8 × 4.1 is about 20 × 4 = 80. The exact answer is 81.18, so it passes the check.
  • 5 mL three times a day for 7 days is about 5 × 3 × 7 = 105 mL. A result of 10.5 mL or 1 050 mL would fail the check.
  • 0.25 g converted to milligrams must give a number bigger than 0.25, because the milligram is a smaller unit. The right answer is 250 mg.

If your answer is ten times too big or too small, the decimal point is in the wrong place. Estimation catches this before it reaches a patient.

Exam focus

  • Roman numerals: you may be asked to read one, for example XLII, or to write 14 as a Roman numeral.
  • Conversion between fractions, decimals and percentages comes up in almost every calculation.
  • Counting significant figures: remember that zeros before the first non-zero digit never count.
  • Safe writing of decimals: a leading zero (0.5 mg) and no trailing zero (5 mg, not 5.0 mg).
  • Common mistake: placing the decimal point wrongly when converting 0.25 g to milligrams.

Quick check

Test yourself before you move on. Pick an answer to see the explanation.

  1. 1.The Roman numeral XLII is equal to:

  2. 2.How many significant figures are in 0.00450?

  3. 3.Rounded to 2 decimal places, 3.4567 is:

  4. 4.The fraction 3/8 written as a decimal is:

  5. 5.Which is the safest way to write five milligrams on a label?

Practise past questions